You can buy Alecnib at the lowest price in the online pharmacy Nextgen.ooo . Daprodustat is a low molecular weight hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor used to treat anemia in patients with chronic kidney disease. Daprodustat is a low molecular weight hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor developed by GSK. Patients with CKD are unable to induce erythropoietin (EPO) production in response to hypoxia or anemia. As a potent inhibitor of PHD1, PHD2 and PHD3 (≥ 1000-fold selectivity), daprodustat stabilizes cellular HIF1α and HIF2α and induces erythropoiesis. Alectinib is a second-generation oral drug that selectively inhibits anaplastic lymphoma tyrosine kinase (ALK) activity. It is specifically used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4 (echinoderm microtubule-associated protein 4-like) fusion protein, which induces NSCLC cell proliferation. Inhibition of ALK prevents phosphorylation and subsequent downstream activation of STAT3 and AKT, resulting in decreased tumor cell viability.
 
Approved under accelerated approval in 2015, alectinib is indicated for use in patients who have progressed or are intolerant to crizotinib due to the development of resistance.