You can buy Eltromdx at the lowest price at Nextgen.ooo online pharmacy. Eltrombopag is used to treat low platelet levels in adults with chronic immune (idiopathic) thrombocytopenia (ITP) when certain other medications or surgery to remove the spleen have not worked well enough. ITP is a condition that can cause unusual bruising or bleeding due to an abnormally low number of platelets in the blood. Eltrombopag was also recently approved for the treatment of thrombocytopenia (low platelet count in the blood) in patients with chronic hepatitis C, allowing them to start and maintain interferon-based therapy.
 
Thrombopoietin receptor agonists are pharmaceutical agents that stimulate the production of platelets in the bone marrow. This is different from the previously discussed agents, which work by trying to limit the destruction of platelets.
 
Eltrombopag is an orally bioavailable TPO receptor agonist that interacts with the transmembrane domain of the human TPO receptor. Eltrombopag is a stimulator of STAT and JAK phosphorylation. Unlike recombinant TPO or romiplostim, eltrombopag does not activate the AKT pathway in any way. Of note, when administered to patients with aplastic anemia, cell lines other than platelets were increased, suggesting that either eltrombopag potentiates the effect of TPO in vivo; or there is an as yet undiscovered mechanism of action.