You can buy Tipanat at the lowest price at Nextgen.ooo online pharmacy. Trifluridine/tipiracil is a fixed-dose combination drug used as a third- or fourth-line treatment for metastatic colorectal or gastric cancer after chemotherapy and targeted therapy have failed. It is a combination of two active pharmaceutical ingredients: trifluridine, a nucleoside analogue, and tipiracil, a thymidine phosphorylase inhibitor. Tipiracil prevents the rapid metabolism of trifluridine, increasing the bioavailability of trifluridine.
 
Trifluridine is incorporated into DNA during DNA synthesis and inhibits tumor cell growth. Trifluridine (TFT) is incorporated into DNA by phosphorylation by thymidylate kinase (TK) to TF-TMP; TF-TMP then covalently binds to tyrosine 146 of the active site of thymidylate synthase (TS), inhibiting the enzyme activity. TS is vital for DNA synthesis because it is the enzyme involved in the synthesis of the deoxynucleotide, thymidine triphosphate (dTTP). Inhibition of TS depletes the cell of dTTP and causes a buildup of deoxyuridine monophosphate (dUMP), which increases the likelihood that uracil will be incorrectly incorporated into DNA. In addition, subsequent phosphorylation of TF-TMP causes increased levels of TF-TTP in the cell, leading to its incorporation into DNA. Although the exact mechanism of how TFT causes DNA damage is not fully understood, it is hypothesized that the incorporation of TF-TTP into DNA leads to the formation of a DNA strand break. Tipiracil prevents the degradation of trifluridine via thymidine phosphorylase (TP) when taken orally and also has antiangiogenic properties. The most common side effects include neutropenia, malaise, fatigue, and anemia.